Lab News

Happy New Year! We are excited to welcome two new Masters 2 interns: Julie Pauliat (who actually did a pre-internship last fall) and Baptiste Demaret. Julie will develop some cool epigenome editing techniques to assess the DNA methylation/polycomb relationship. Baptiste will work with Priscillia to assess enhancer regulation during ESC differentiation. 

The project that started the lab is out in NSMB! This was a tremendous team effort led by Julien, Teresa and Ana, with key experiments from Margherita and Angelique. We also had many former members chip in (Amina, Anna, and Cara). Check out this Twitter thread from Julien for more details, or read the paper here!

Ana and Julien's paper on the impact of DNA methylation on CTCF binding is out in Nucleic Acids Research!!! Congrats to all the authors on this major lab achievement! Link Twitter

Welcome to our newest post-doc, Marlet Morales Franco!! Marlet is a computational biologist who did her PhD with Robert Schneider (LMU Munich), where she studied transcriptional noise in yeast. She will be honing her skills in mammalian (epi)genomics with us, as she will integrate many data sets we are generating to assess enhancer function. We look forward to see what she finds!

Congrats Teresa for successfully obtaining a 4th year PhD fellowship from Labex!!! 🥳

New review is out today! Ana led this in collaboration with our friend Daan Noordermeer, where we summarized the current understanding of the impact of DNA methylation on CTCF binding and 3D genome organization. 

Welcome Hortense Bouvier! Hortense is part of the Magistère de Génétique, and will work with Priscillia to help us understand how enhancers are regulated during differentiation. 

Our next original research article posted to BioRxiv! Here we show how the de novo DNA methylation program influences CTCF binding and the 3D cis-regulatory landscape. This work was led by Ana and Julien with a lot of help from Margherita! BioRxiv Twitter thread

First lab original research article posted to BioRxiv! Here we show how DNA methylation shapes H3K27me3 patterning during ESC differentiation, and in some cases this can lead to gene activation, which we demonstrated with epigenome editing. This work was led by Julien, Teresa and Ana BioRxiv Twitter thread

New review from the lab by Julien and Max on non-canonical imprinting, published in Development! Link

It's very sad day, as our beloved Ana is leaving the lab to start a new phase of her career in industry, focused on human reproduction, in Valenca, Spain. She was the first post-doc in the lab, and the driving force of many of the projects that helped get our research program off the ground. She also was instrumental in training many of the students and engineers that came through. We will miss her dearly, but are very excited for her new horizons! 

Welcome Margherita Scarpa, our new engineer and lab manager! Margherita is Italian, but spent most of her career in Spain. Her research will focus on implementing epigenome editing (in addition to making sure the lab doesn't catch on fire). 

Welcome Pol Arnau Romero to the group! Orginally from Barcelona, he is part of the EUR G.E.N.E. international masters program affiliated with Université Paris Cité. He will work with Priscillia to help characterize the role of DNA methylation at enhancers. As a bonus, he is fluent in all the native languages spoken in the lab: French, English, Italian, and Spanish (plus Catalan)!

We are recruiting a research engineer! More info here: Join Us! 

Congratulations to Priscillia! The first ever recipient of the Prix Georges Brahms from the Fondation CNRS! Here she is with the head of CNRS, Antoine Petit, after the ceremony. We are incredibly proud!!! 

We have hired! Welcome Amina Sultanova to the team! Amina will be providing lab support, and her research will be focused on implementing and improving our epigenome editing tools. 

We are recruiting a research engineer! More info here: Join Us! 

We are incredibly excited to announce that Angelique David has been selected for a doctoral fellowship from the BioSPC! Angelique did stellar work during her masters, and we can't wait to see how she continues to develop her project!

We have our first summer intern! Cara McQuillen is a student at the University of Chicago (USA), and will spend the summer helping Teresa implement her epigenome editing system. 

Incredible news for Priscillia! She has been officially selected for a permanent researcher position (Chargé de Recherche, Classe Normale) by the CNRS. This is very competitive, and gives Priscillia long term job security. It also means she can stay with the Greenberg Lab as long as she wants, which makes us very happy!!! 

Congratulations to Julien, second author on a paper published in PLoS Genetics in a collaboration led by our good friends down the hall in Vanessa Ribes' lab! Read more here: Link

Welcome to Angélique David, a Masters (M2) student from the Magistère de Génétique program! Angélique will try to gain insights into the intriguing relationship between DNA methylation and histone marks at gene promoters. 

Welcome to our newest post-doc, Priscillia Lhoumaud! Priscillia brings a lot of experience in epigenetics from fly and mammalian models, most recently in the lab of Jane Skok at New York University (USA). She will generate technology to interrogate enhancer regulation as part of the ANR REMEDY project. 

Bittersweet day in the Greenberg Lab. Thomas Damagnez was the first recruit in the Greenberg lab, and has been here since the beginning. He will be leaving for a new position at Novogene Europe. We are very happy for him, but the lab won't be the same. He will be missed!!

Welcome to Roshani Singh—a Masters 2 student from the CRI program! She will edit the epigenome at some of our interesting (we hope) targets. 

We have our first PhD student! Teresa Urli will continue her work from her M2, focused on mechanisms of epigenetic reprogramming.

We are excited to announce that the ANR has funded a formal collaboration between the Greenberg lab, our good friends at Pierre Defossez' lab across the street at the Epigenetics & Cell Fate Unit (U of Paris), and Salvatore Spicuglia's group at the TAGC in Marseille. We are looking forward to get rolling! Watch this space! 

Julien and Max just published a News & Views on two papers published in Nature Genetics about Polycomb/PRC1 in mouse development. Check it out! Link